Propylthiouracil
Propylthiouracil 50mg Antithyroid Agent 200Tablets
Propylthiouracil is available as a tablet containing Propylthiouracil 50 mg.
How does it work?
Propylthiouracil acts on the thyroid to reduce overactivity.
How do I take it?
Treatment is started at high dosage often 300-600mg per day taken as 2-3 divided dosages and is maintained until the patient’s thyroid returns to normal activity. Subsequent therapy may then be given in one of two ways.
1. Maintenance Regimen The dosage is gradually decreased so as to maintain normal thyroid activity. This maintenance dosage can vary from patient to patient in the range 50-150mg per day which may be taken as a single daily dosage. Therapy is usually continued for 12-18 months.
2. Block-replacement regimen In some the dosage is maintained at the initial high level (i.e. 300-600mg per day) and supplemental thyroxine (50-150mcg per day) is also given in order to prevent an underactive thyroid induced by the high dosage of propylthiouracil. Therapy is continued for 12-18 months.
What side effects can be expected?
Adverse reactions if they occur usually are seen in the first 8 weeks of treatment.
* Headaches, nausea, joint pains, stomach upset.
* Skin rashes are common in possibly 1 in 50 patients. If it occurs cease the drug and contact your doctor.
* Rarely alopecia, hepatitis, vasculitis and lupus erythematous-like syndrome
* A rare side effect is bone marrow depression which can present in 1 in 1000 patients. This presents as a severe sore throat, mouth ulcers, fever. If it occurs cease the drug and contact your doctor immediately. The suppression of the bone marrow is often temporary with the bone marrow recovering after 1-2 week.
Propylthiouracil during pregnancy and lactation
Propylthiouracil is used in pregnancy but the specialist will aim to use the lowest dosage possible and will not use the drug combined with thyroxine. The reason for this is that propylthiouracil does cross the placenta into the baby so the lowest dosage is preferred.
Propylthiouracil does enter mother’s milk and although this does not preclude breast feeding it is essential that baby is closely monitored and the lowest effective dose is used. Some for safety reasons advise no breast feeding.
Storing Propylthiouracil
tablets should be stored at room temperature. Keep in the original container in which they have been dispensed and protect from direct sunlight.
See more
The Author Dan Clanton information reviews
